Biomolecules
Antibody-matched peptide reagents for immunodepletion, immunocompetition and western blot validationOur biomolecules range supplies two antibody-matched reagent formats: synthetic blocking peptides for immunodepletion and immunocompetition, and positive control preparations for western blot. Every product record identifies the specific antibody catalogue number it is designed to pair with, spanning targets across receptor signaling, kinase biology, channel physiology and membrane trafficking research.
Browse BiomoleculesTwo Reagent Formats Matched to Named Antibodies
Each product in our biomolecules range is built around a target-specific synthetic peptide and listed against the antibody catalogue number it corresponds to. The format determines how the peptide is used in the experiment, and product records identify both the corresponding antibody and the peptide region.
Two Antibody-Matched Pairs Worth a Closer Look
Ser81 is the most heavily phosphorylated site on the androgen receptor following androgen binding, and AQP4 is the most abundant water channel in the brain, making both targets frequent points of reference in their respective research fields. Each pairing below combines a phospho- or target-specific blocking peptide with its matched positive control.
Androgen Receptor Positive Control, Phospho-Ser81 (STJ505896)
Ser81 phosphorylation on the androgen receptor is co-sustained by CDK1 and CDK9 and is linked to nuclear localization and transactivation of AR target genes, including occupancy at the PSA enhancer-promoter loop in prostate cancer models.11 This phospho-specific positive control is paired with the matching blocking peptide (STJ505895) for immunodepletion and immunocompetition work on the same modification.
View product →Aquaporin 4 Positive Control (STJ503676)
AQP4 is the most abundant water channel in the brain, concentrated at the astrocyte end-feet that border blood vessels, where it controls bidirectional water movement, contributes to glymphatic fluid clearance and has been linked to beta-amyloid clearance in Alzheimer's disease research.7 The matching blocking peptide (STJ503664) supports immunodepletion and immunocompetition experiments against the same target.
View product →Blocking Peptides & Positive Controls for GPCR & Neuropeptide Receptor Research
5-HT1A and 5-HT2A are G protein-coupled serotonin receptors that signal in the central nervous system through Gq/G11 coupling and phospholipase C activation, with 5-HT2A implicated in learning, memory consolidation and the pharmacology of hallucinogenic compounds.1,2 The apelin receptor (APJ) is a separate class A GPCR that shares sequence homology with the angiotensin II receptor and mediates the cardiovascular actions of its ligand apelin, including positive inotropic effects on the heart and endothelium-dependent vasodilation.3 Blocking peptides and positive controls across these targets support antibody validation work in serotonergic and apelinergic signaling studies.
Blocking Peptides & Positive Controls for Kinase Signaling Research
ABL1 and ABL2 are non-receptor tyrosine kinases, with ABL1 forming the oncogenic BCR-ABL1 fusion kinase that drives chronic myeloid leukemia through constitutive tyrosine phosphorylation of downstream substrates.4 ACK1 (TNK2) is a cytoplasmic non-receptor tyrosine kinase that transduces signals from activated receptor tyrosine kinases and is aberrantly activated across a wide range of cancer types, including through its phosphorylation of the androgen receptor in hormone-refractory prostate cancer.5 Blocking peptides and positive controls for these kinases and for AATK support antibody validation work in cancer signaling models.
Blocking Peptides & Positive Controls for Aquaporin Research
AQP1 is extremely abundant in the proximal tubule and descending thin limb of the nephron, where it is essential for urinary concentration, while AQP3 sits in the basolateral membrane of collecting duct principal cells and provides an exit pathway for water reabsorbed apically through AQP2.6 Beyond the kidney, the aquaporin family extends into secretory and barrier tissues across the body. Blocking peptides and positive controls across these targets support antibody validation work in renal and epithelial physiology research.
Blocking Peptides & Positive Controls for cAMP Signaling Research
Adenylate cyclases convert ATP into cyclic AMP downstream of Gs- and Gi-coupled GPCRs, with nine transmembrane isoforms (ADCY1-9) partitioning into distinct plasma membrane microdomains to generate compartmentalized cAMP signals.8 ADCY2, ADCY3 and ADCY8 are among the calcium-stimulated isoforms studied in metabolic signaling, with circulating ADCY8 levels reported to be significantly higher in patients with obesity and type 2 diabetes alongside elevated plasma cAMP.9 Blocking peptides and positive controls across the ADCY family support antibody validation work in cAMP signaling research.
Blocking Peptides & Positive Controls for Annexin & Membrane Trafficking Research
Annexins are calcium-dependent, phospholipid-binding proteins that link membranes to the cytoskeleton and to other membranes. Annexin A2 regulates vascular integrity during acute inflammation through its interaction with actin and adherens junction VE-cadherin, and contributes to lysosome repair and autophagosome biogenesis in the inflammatory response.10 Blocking peptides and positive controls for annexin A1, A2, A6 and other family members support antibody validation work in membrane trafficking and inflammation research.
Looking for a Specific Target?
Browse our full range of blocking peptides and antibody-matched positive controls, covering targets across receptor signaling, kinase biology, channel physiology and membrane trafficking research.
Browse Biomolecules