ABL2 Blocking Peptide for STJ506089 peptide (STJ505824)


Free Shipping
Current Stock:
Applications: Immunodepletion/Immunocompetition
Short Description: ABL2 Blocking Peptide for STJ506089 is synthetically produced from the 1100-1150 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: ABL2
Gene ID: 27
Uniprot ID: ABL2_HUMAN
Immunogen Region: 1100-1150
Specificity: This blocking peptide is recommended for use in combination with ABL2 antibody, STJ506089
Immunogen: Synthetic peptide corresponding to amino acids within region 1100-1150 on human Tyrosine-protein kinase ABL2/ARG.
Tissue Specificity Widely expressed.
Post Translational Modifications Phosphorylated at Tyr-261 by ABL1 in response to oxidative stress. Phosphorylated by PDGFRB. Polyubiquitinated. Polyubiquitination of ABL2 leads to degradation.
Function Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement).CTTN (involved in signaling).or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1.
Peptide Name Tyrosine-Protein Kinase Abl2
Abelson Murine Leukemia Viral Oncogene Homolog 2
Abelson Tyrosine-Protein Kinase 2
Abelson-Related Gene Protein
Tyrosine-Protein Kinase Arg
Database Links Reactome: R-HSA-428890
Reactome: R-HSA-9013149
Reactome: R-HSA-9013423
Reactome: R-HSA-9706369
Cellular Localisation Cytoplasm
Alternative Peptide Names Tyrosine-Protein Kinase Abl2 protein
Abelson Murine Leukemia Viral Oncogene Homolog 2 protein
Abelson Tyrosine-Protein Kinase 2 protein
Abelson-Related Gene Protein protein
Tyrosine-Protein Kinase Arg protein
ABL2 protein
ABLL protein
ARG protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance