5HT1A Blocking Peptide for STJ500001 peptide (STJ503611)
SPECIFICATIONS
ImmunogenSynthetic peptide corresponding to amino acids within region 200-250 on rat 5-hydroxytrptamine receptor 1A protein.
General Information
| Short Description | 5HT1A Blocking Peptide for STJ500001 is synthetically produced from the 200-250 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Htr1a |
| Gene ID | 24473 |
| Uniprot ID | 5HT1A_RAT |
| Immunogen | Synthetic peptide corresponding to amino acids within region 200-250 on rat 5-hydroxytrptamine receptor 1A protein. |
| Immunogen Region | 200-250 |
| Specificity | This blocking peptide is recommended for use in combination with 5HT1A antibody, STJ500001 |
Additional Info
| Tissue Specificity | Detected in hypothalamus, mesencephalon, amygdala, medulla, thalamus, septum and hippocampus. |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes. |
| Peptide Name | 5-Hydroxytryptamine Receptor 1a5-Ht-1a5-Ht1aSerotonin Receptor 1a |
| Database Links | Reactome: R-RNO-390666 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionDendrite |
| Alternative Peptide Names | 5-Hydroxytryptamine Receptor 1a protein5-Ht-1a protein5-Ht1a proteinSerotonin Receptor 1a proteinHtr1a protein5ht1a protein |
Information sourced from Uniprot.org