5HT1A Blocking Peptide for STJ500001 peptide (STJ503611)

SKU:
STJ503611-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: 5HT1A Blocking Peptide for STJ500001 is synthetically produced from the 200-250 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Htr1a
Gene ID: 24473
Uniprot ID: 5HT1A_RAT
Immunogen Region: 200-250
Specificity: This blocking peptide is recommended for use in combination with 5HT1A antibody, STJ500001
Immunogen: Synthetic peptide corresponding to amino acids within region 200-250 on rat 5-hydroxytrptamine receptor 1A protein.
Tissue Specificity Detected in hypothalamus, mesencephalon, amygdala, medulla, thalamus, septum and hippocampus.
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
Peptide Name 5-Hydroxytryptamine Receptor 1a
5-Ht-1a
5-Ht1a
Serotonin Receptor 1a
Database Links Reactome: R-RNO-390666
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Dendrite
Alternative Peptide Names 5-Hydroxytryptamine Receptor 1a protein
5-Ht-1a protein
5-Ht1a protein
Serotonin Receptor 1a protein
Htr1a protein
5ht1a protein

Information sourced from Uniprot.org

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