Annexin A2 Blocking Peptide peptide (Phospho) (STJ504527)
SPECIFICATIONS
ImmunogenSynthetic peptide corresponding to Human Annexin A2 protein with phosphorylated serine 12 and threonine 18 residues. Synthetic peptide was taken within amino acid region 1-50.
General Information
| Short Description | Phospho-Annexin A2 Blocking Peptide is synthetically produced from the 1-50 aa sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | ANXA2 |
| Gene ID | 302 |
| Uniprot ID | ANXA2_HUMAN |
| Immunogen | Synthetic peptide corresponding to Human Annexin A2 protein with phosphorylated serine 12 and threonine 18 residues. Synthetic peptide was taken within amino acid region 1-50. |
| Immunogen Region | 1-50 aa |
Additional Info
| Post Translational Modifications | Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. ISGylated. |
| Function | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. |
| Peptide Name | Annexin A2Annexin IiAnnexin-2Calpactin I Heavy ChainCalpactin-1 Heavy ChainChromobindin-8Lipocortin IiPlacental Anticoagulant Protein IvPap-IvProtein IP36 |
| Database Links | Reactome: R-HSA-445355Reactome: R-HSA-6798695Reactome: R-HSA-75205Reactome: R-HSA-8950505 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixBasement MembraneMelanosomeIn The Lamina Beneath The Plasma MembraneIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvTranslocated From The Cytoplasm To The Cell Surface Through A Golgi-Independent Mechanism |
| Alternative Peptide Names | Annexin A2 proteinAnnexin Ii proteinAnnexin-2 proteinCalpactin I Heavy Chain proteinCalpactin-1 Heavy Chain proteinChromobindin-8 proteinLipocortin Ii proteinPlacental Anticoagulant Protein Iv proteinPap-Iv proteinProtein I proteinP36 proteinANXA2 proteinANX2 proteinANX2L4 proteinCAL1H proteinLPC2D protein |
Information sourced from Uniprot.org