Cytokines
Cytokines in this range are small secreted signalling proteins produced recombinantly in CHO, HEK293, insect cell or yeast host systems, supplied unconjugated and ready for use in cell culture and functional assay work. The range spans interleukins, interferons, checkpoint ligands and metabolic signalling proteins that bind specific receptors on target cells to trigger transduction pathways controlling gene expression.
Browse CytokinesTwo Cytokines Central to Current Immunology Research
PD-L1 and IL-12 were chosen for how frequently they appear in checkpoint and innate immunity literature. PD-L1 defines one of the most widely studied coinhibitory pathways in cancer immunology, while IL-12 sits at the centre of NK and Th1 cell activation. Both are supplied with functional validation data on their own product datasheets.
Human PD-L1 (B7-H1) Protein (STJP000698)
PD-L1 engages the PD-1 receptor on activated T cells, inhibiting T cell receptor-mediated proliferation and cytokine secretion.1 This HEK293-expressed protein has been used in flow cytometry studies analysing tolerogenic dendritic cell markers, including PD-L1 alongside TLR-2, GILZ and ILT3, on dendritic cells generated under different culture conditions.
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Human Interleukin-12 Protein (STJP000505)
IL-12 drives NK cell and Th1 cell activation and is commonly paired with IL-18 in innate immune studies. This HEK293-expressed protein has been used in a co-culture study with Plasmodium falciparum-infected erythrocytes, where NK cell gene regulation was assessed following stimulation with IL-12 and IL-18 together.
View product →Cytokines for Immune Checkpoint Research
Secreted proteins that regulate T cell activation through coinhibitory or immunoregulatory signalling. PD-L1 (B7-H1) binds PD-1 to inhibit T cell receptor-mediated proliferation and cytokine secretion.1 IL-27 and IL-35 are both members of the IL-12 cytokine family with immunoregulatory roles distinct from IL-12 itself, and B7-H4 is a coinhibitory B7 family ligand studied for its role in tumour immune evasion. These targets are used in studies mapping the balance between immune activation and suppression in tumour and inflammatory settings.
Cytokines for Interferon and Antiviral Signalling Research
Type I, II and III interferons for studies of antiviral defence and immune regulation. Interferon-beta 1a and interferon-beta 1b are both type I interferons used in demyelinating disease research, interferon-gamma is the principal type II interferon produced by activated T cells and NK cells, and IL-28B (interferon lambda 3) is a type III interferon with antiviral activity concentrated in epithelial tissue. These proteins are used across studies of innate antiviral responses and interferon-driven signalling in immune and epithelial cells.
Cytokines for Interleukin and Innate Immunity Research
Interleukins spanning NK cell activation, T cell proliferation and regulatory signalling. IL-12 drives NK and Th1 cell activation, commonly studied alongside IL-18, IL-2 is the founding T cell growth factor used in proliferation and expansion assays, IL-6 is a pleiotropic cytokine acting on both immune and non-immune cells, and IL-10 is a principal anti-inflammatory cytokine that limits innate immune responses. These interleukins are used across cell culture, differentiation and functional bioassay work spanning innate and adaptive immunity.
Cytokines for Metabolic and Vascular Signalling Research
Secreted proteins with roles spanning metabolism, haematopoiesis and vascular biology. Adiponectin is an adipocyte-derived hormone involved in glucose and lipid metabolism, ACE-2 is the enzyme receptor that regulates the renin-angiotensin system and also serves as the entry receptor for SARS-CoV-2 and SARS-CoV, erythropoietin-alpha stimulates red blood cell production from haematopoietic progenitors, and hepatocyte growth factor signals through the c-MET receptor to drive cell proliferation and tissue repair. These targets support work in metabolic signalling, haematopoiesis and growth factor receptor biology.
Looking for a Specific Cytokine?
Browse the full cytokines and growth factors range, including interleukins, colony-stimulating factors and receptor subunits, or contact us if a specific target is not listed.
Browse Cytokines1. Freeman GJ, Long AJ, Iwai Y, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med. 2000;192(7):1027-1034.