Annexin A2 Positive Control peptide (Phospho) (STJ504567)
SPECIFICATIONS
General Information
| Short Description | Phospho-Annexin A2 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | WB |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | WB: 1:500 |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | ANXA2 |
| Gene ID | 302 |
| Uniprot ID | ANXA2_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. ISGylated. |
| Function | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. |
| Peptide Name | Annexin A2Annexin IiAnnexin-2Calpactin I Heavy ChainCalpactin-1 Heavy ChainChromobindin-8Lipocortin IiPlacental Anticoagulant Protein IvPap-IvProtein IP36 |
| Database Links | Reactome: R-HSA-445355Reactome: R-HSA-6798695Reactome: R-HSA-75205Reactome: R-HSA-8950505 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixBasement MembraneMelanosomeIn The Lamina Beneath The Plasma MembraneIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvTranslocated From The Cytoplasm To The Cell Surface Through A Golgi-Independent Mechanism |
| Alternative Peptide Names | Annexin A2 proteinAnnexin Ii proteinAnnexin-2 proteinCalpactin I Heavy Chain proteinCalpactin-1 Heavy Chain proteinChromobindin-8 proteinLipocortin Ii proteinPlacental Anticoagulant Protein Iv proteinPap-Iv proteinProtein I proteinP36 proteinANXA2 proteinANX2 proteinANX2L4 proteinCAL1H proteinLPC2D protein |
Information sourced from Uniprot.org