Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. ISGylated.
Function
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen.
Peptide Name
Annexin A2Annexin IiAnnexin-2Calpactin I Heavy ChainCalpactin-1 Heavy ChainChromobindin-8Lipocortin IiPlacental Anticoagulant Protein IvPap-IvProtein IP36
SecretedExtracellular SpaceExtracellular MatrixBasement MembraneMelanosomeIn The Lamina Beneath The Plasma MembraneIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvTranslocated From The Cytoplasm To The Cell Surface Through A Golgi-Independent Mechanism
Alternative Peptide Names
Annexin A2 proteinAnnexin Ii proteinAnnexin-2 proteinCalpactin I Heavy Chain proteinCalpactin-1 Heavy Chain proteinChromobindin-8 proteinLipocortin Ii proteinPlacental Anticoagulant Protein Iv proteinPap-Iv proteinProtein I proteinP36 proteinANXA2 proteinANX2 proteinANX2L4 proteinCAL1H proteinLPC2D protein
