Recombinant Antibodies

Primary Antibodies

Recombinant Antibodies

260+ recombinant antibodies produced using synthetic gene technology

Recombinant antibodies, or rAbs, are monoclonal antibodies produced in vitro from synthetic genes rather than through animal immunisation and hybridoma technology, making their production more humane and efficient than traditional monoclonal antibodies.

How it works

How recombinant antibodies are made

Producing a recombinant antibody begins with synthesising the genetic sequence that encodes the antibody of interest, rather than immunising a live animal. That synthetic gene is cloned into an expression vector and introduced into a host cell line, which is cultured to manufacture the antibody at scale. Across our range, the host listed for a given product refers to this expression system rather than an animal that was immunised, and includes mouse, rabbit and human antibody sequences expressed in host systems such as CHO cells.

Category benefits

Why use recombinant antibodies?

✓ Produced without animals or hybridomas
Because the antibody gene is synthesised and cloned directly, recombinant antibodies do not require an animal to be immunised or a hybridoma cell line to be maintained.
✓ Consistent from batch to batch
Since every recombinant antibody is expressed from the same defined genetic sequence, each production run closely matches the last, reducing lot-to-lot variation.
✓ Monoclonal by nature
Every recombinant antibody in our range is monoclonal, since the cloned gene encodes a single, defined antibody sequence rather than a mixed population.
Where they're used

Typical applications

✓ Core protein detection techniques
Recombinant antibodies are used across core detection methods including Western blotting, immunohistochemistry, immunofluorescence and flow cytometry.
✓ Structural and biophysical studies
Recombinant expression can generate antibody at milligram scale, which supports structural work such as crystallography more reproducibly than antibody obtained from hybridoma culture.
✓ Diagnostic assay development
Recombinant antibodies raised against defined viral or bacterial targets are used in diagnostic formats such as lateral flow tests, including antigen tests developed against SARS-CoV-2 surface proteins.
✓ Antibody validation and reproducibility work
Because a recombinant antibody's sequence is fixed and does not drift between production runs, sequence-defined recombinant antibodies have been proposed as a route to improving reproducibility across biomedical research.

Need help choosing an antibody?

Contact our technical support team for help selecting an antibody for your target of interest. Each product page includes a downloadable datasheet and safety data sheet, with dispatch on overnight priority shipping with gel ice packs.

Looking for more primary antibodies?

Browse our full range of primary antibodies, including monoclonal, polyclonal and PTM antibodies.

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