Anti-LSR antibody (50-240) (STJ111665)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal LSR (50-240) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LSR |
| Gene ID | 51599 |
| Uniprot ID | LSR_HUMAN |
| Immunogen Region | 50-240 |
| Immunogen Sequence | ALLAGGLSRGLGSHPAAAGR DAVVFVWLLLSTWCTAPARA IQVTVSNPYHVVILFQPVTL PCTYQMTSTPTQPIVIWKYK SFCRDRIADAFSPASVDNQL NAQLAAGNPGYNPYVECQDS VRTVRVVATKQGNAVTLGDY YQGRRITITGNADLTFDQTA WGDSGVYYCSVVSAQDLQGN NEAYAELIVLD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 50-240 of human LSR (NP_057009.3). |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-365 by MAPK8/JNK1 and MAPK9/JNK2 may be required for exclusive localization at tricellular tight junstions. Polyubiquitinated at Lys-638 via 'Lys-63'-linked ubiquitin chains.deubiquitinated by USP53. |
| Function | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells. Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions. |
| Protein Name | Lipolysis-Stimulated Lipoprotein ReceptorAngulin-1 |
| Database Links | Reactome: R-HSA-8964038Reactome: R-HSA-8964046 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionTight JunctionLocated At Tricellular Contacts |
| Alternative Antibody Names | Anti-Lipolysis-Stimulated Lipoprotein Receptor antibodyAnti-Angulin-1 antibodyAnti-LSR antibodyAnti-ILDR3 antibodyAnti-LISCH antibody |
Information sourced from Uniprot.org