| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LSR (50-240) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LSR |
| Gene ID: |
51599 |
| Uniprot ID: |
LSR_HUMAN |
| Immunogen Region: |
50-240 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 50-240 of human LSR (NP_057009.3). |
| Immunogen Sequence: |
ALLAGGLSRGLGSHPAAAGR DAVVFVWLLLSTWCTAPARA IQVTVSNPYHVVILFQPVTL PCTYQMTSTPTQPIVIWKYK SFCRDRIADAFSPASVDNQL NAQLAAGNPGYNPYVECQDS VRTVRVVATKQGNAVTLGDY YQGRRITITGNADLTFDQTA WGDSGVYYCSVVSAQDLQGN NEAYAELIVLD |
| Post Translational Modifications | Phosphorylation at Ser-365 by MAPK8/JNK1 and MAPK9/JNK2 may be required for exclusive localization at tricellular tight junstions. |
| Function | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells. Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions. |
| Protein Name | Lipolysis-Stimulated Lipoprotein ReceptorAngulin-1 |
| Database Links | Reactome: R-HSA-8964038Reactome: R-HSA-8964046 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionTight JunctionLocated At Tricellular Contacts |
| Alternative Antibody Names | Anti-Lipolysis-Stimulated Lipoprotein Receptor antibodyAnti-Angulin-1 antibodyAnti-LSR antibodyAnti-ILDR3 antibodyAnti-LISCH antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
