• Western blot analysis of extracts of various cell lines, using LSR antibody (STJ111665) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
  • Western blot analysis of extracts of various cell lines, using LSR antibody (STJ111665) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.

Anti-LSR antibody (50-240) (STJ111665)

SKU:
STJ111665

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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-LSR (50-240) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: LSR
Gene ID: 51599
Uniprot ID: LSR_HUMAN
Immunogen Region: 50-240
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 50-240 of human LSR (NP_057009.3).
Immunogen Sequence: ALLAGGLSRGLGSHPAAAGR DAVVFVWLLLSTWCTAPARA IQVTVSNPYHVVILFQPVTL PCTYQMTSTPTQPIVIWKYK SFCRDRIADAFSPASVDNQL NAQLAAGNPGYNPYVECQDS VRTVRVVATKQGNAVTLGDY YQGRRITITGNADLTFDQTA WGDSGVYYCSVVSAQDLQGN NEAYAELIVLD
Post Translational Modifications Phosphorylation at Ser-365 by MAPK8/JNK1 and MAPK9/JNK2 may be required for exclusive localization at tricellular tight junstions.
Function Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells. Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions.
Protein Name Lipolysis-Stimulated Lipoprotein Receptor
Angulin-1
Database Links Reactome: R-HSA-8964038
Reactome: R-HSA-8964046
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Tight Junction
Located At Tricellular Contacts
Alternative Antibody Names Anti-Lipolysis-Stimulated Lipoprotein Receptor antibody
Anti-Angulin-1 antibody
Anti-LSR antibody
Anti-ILDR3 antibody
Anti-LISCH antibody

Information sourced from Uniprot.org

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