Human TNFRSF10D/DcR2/TRAIL-R4/CD264 protein (Recombinant) (C-hFc & His) (STJP002679)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenActive Recombinant Human TNFRSF10D/DcR2/TRAIL-R4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala 56-His 211) of human DcR2 (Accession #NP_003831.2) fused with an Fc, 6×His tag at the C-terminu
General Information
| Short Description | Recombinant-Human TNFRSF10D/DcR2/TRAIL-R4/CD264-C-hFc & His protein was developed in hek293 cells using the region Ala 56-His 211. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | 1.Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human TRAIL at 2 Mu g/mL (100 Mu L/well) can bind Recombinant Human DcR2 with a linear range of 15-60 ng/mL.|2.Measured by its ability to inhibit TRAIL-mediated cytotoxi |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | TNFRSF10D |
| Gene ID | 8793 |
| Uniprot ID | TR10D_HUMAN |
| Immunogen | Active Recombinant Human TNFRSF10D/DcR2/TRAIL-R4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala 56-His 211) of human DcR2 (Accession #NP_003831.2) fused with an Fc, 6×His tag at the C-terminu |
| Immunogen Region | Ala 56-His 211 |
| Immunogen Sequence | ATIPRQDEVPQQTVAPQQQR RSLKEEECPAGSHRSEYTGA CNPCTEGVDYTIASNNLPSC LLCTVCKSGQTNKSSCTTTR DTVCQCEKGSFQDKNSPEMC RTCRTGCPRGMVKVSNCTPR SDIKCKNESAASSTGKTPAA EETVTTILGMLASPYH |
Additional Info
| Function | Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. it cannot but it can induce the NF-kappa-B pathway. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 10dDecoy Receptor 2Dcr2Tnf-Related Apoptosis-Inducing Ligand Receptor 4Trail Receptor 4Trail-R4Trail Receptor With A Truncated Death DomainCd Antigen Cd264 |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-6803211Reactome: R-HSA-75158 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 10d proteinDecoy Receptor 2 proteinDcr2 proteinTnf-Related Apoptosis-Inducing Ligand Receptor 4 proteinTrail Receptor 4 proteinTrail-R4 proteinTrail Receptor With A Truncated Death Domain proteinCd Antigen Cd264 proteinTNFRSF10D proteinDCR2 proteinTRAILR4 proteinTRUNDD proteinUNQ251 proteinPRO288 protein |
Information sourced from Uniprot.org