Host: | HEK293 cells |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Recombinant-Human TNFRSF10D/DcR2/TRAIL-R4/CD264-C-hFc & His protein was developed from hek293 cells and has a target region of C-hFc & His. For use in research applications. |
Formulation: | Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Immunoreactivity: | 1.Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human TRAIL at 2 Mu g/mL (100 Mu L/well) can bind Recombinant Human DcR2 with a linear range of 15-60 ng/mL.2.Measured by its ability to inhibit TRAIL-mediated cytotoxic |
Gene Symbol: | TNFRSF10D |
Gene ID: | 8793 |
Uniprot ID: | TR10D_HUMAN |
Immunogen Region: | Ala 56-His 211 |
Immunogen: | Active Recombinant Human TNFRSF10D/DcR2/TRAIL-R4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala 56-His 211) of human DcR2 (Accession #NP_003831.2) fused with an Fc, 6×His tag at the C-terminu |
Function | Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. it cannot but it can induce the NF-kappa-B pathway. |
Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 10d Decoy Receptor 2 Dcr2 Tnf-Related Apoptosis-Inducing Ligand Receptor 4 Trail Receptor 4 Trail-R4 Trail Receptor With A Truncated Death Domain Cd Antigen Cd264 |
Database Links | Reactome: R-HSA-202733 Reactome: R-HSA-6803211 Reactome: R-HSA-75158 |
Cellular Localisation | Membrane Single-Pass Type I Membrane Protein |
Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 10d protein Decoy Receptor 2 protein Dcr2 protein Tnf-Related Apoptosis-Inducing Ligand Receptor 4 protein Trail Receptor 4 protein Trail-R4 protein Trail Receptor With A Truncated Death Domain protein Cd Antigen Cd264 protein TNFRSF10D protein DCR2 protein TRAILR4 protein TRUNDD protein UNQ251 protein PRO288 protein |
Information sourced from Uniprot.org