| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human TNFRSF10D/DcR2/TRAIL-R4/CD264-C-hFc & His protein was developed from hek293 cells and has a target region of C-hFc & His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: |
1.Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human TRAIL at 2 Mu g/mL (100 Mu L/well) can bind Recombinant Human DcR2 with a linear range of 15-60 ng/mL.2.Measured by its ability to inhibit TRAIL-mediated cytotoxic |
| Gene Symbol: |
TNFRSF10D |
| Gene ID: |
8793 |
| Uniprot ID: |
TR10D_HUMAN |
| Immunogen Region: |
Ala 56-His 211 |
| Immunogen: |
Active Recombinant Human TNFRSF10D/DcR2/TRAIL-R4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala 56-His 211) of human DcR2 (Accession #NP_003831.2) fused with an Fc, 6×His tag at the C-terminu |
| Function | Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. it cannot but it can induce the NF-kappa-B pathway. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 10dDecoy Receptor 2Dcr2Tnf-Related Apoptosis-Inducing Ligand Receptor 4Trail Receptor 4Trail-R4Trail Receptor With A Truncated Death DomainCd Antigen Cd264 |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-6803211Reactome: R-HSA-75158 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 10d proteinDecoy Receptor 2 proteinDcr2 proteinTnf-Related Apoptosis-Inducing Ligand Receptor 4 proteinTrail Receptor 4 proteinTrail-R4 proteinTrail Receptor With A Truncated Death Domain proteinCd Antigen Cd264 proteinTNFRSF10D proteinDCR2 proteinTRAILR4 proteinTRUNDD proteinUNQ251 proteinPRO288 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
