Human NKX2-5 protein (Recombinant) (N-GST & C-His) (STJP007746)

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STJP007746
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human NKX2-5-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: NKX2-5
Gene ID: 1482
Uniprot ID: NKX25_HUMAN
Immunogen Region: Ser146-Gly206
Immunogen: Homo sapiens (Human)
Function Transcription factor required for the development of the heart and the spleen. During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4. May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal. Binds to the core DNA motif of NPPA promoter. Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression. Positively regulates transcription of genes such as COL3A1 and MMP2, resulting in increased pulmonary endothelial fibrosis in response to hypoxia.
Protein Name Homeobox Protein Nkx-2.5
Cardiac-Specific Homeobox
Homeobox Protein Csx
Homeobox Protein Nk-2 Homolog E
Database Links Reactome: R-HSA-2032785
Reactome: R-HSA-5578768
Reactome: R-HSA-9733709
Cellular Localisation Nucleus
Alternative Protein Names Homeobox Protein Nkx-2.5 protein
Cardiac-Specific Homeobox protein
Homeobox Protein Csx protein
Homeobox Protein Nk-2 Homolog E protein
NKX2-5 protein
CSX protein
NKX2.5 protein
NKX2E protein

Information sourced from Uniprot.org

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