Human NKX2-5 protein (Recombinant) (N-GST & C-His) (STJP007746)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human NKX2-5-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | NKX2-5 |
| Gene ID | 1482 |
| Uniprot ID | NKX25_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser146-Gly206 |
Additional Info
| Function | Transcription factor required for the development of the heart and the spleen. During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4. May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal. Binds to the core DNA motif of NPPA promoter. Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression. Positively regulates transcription of genes such as COL3A1 and MMP2, resulting in increased pulmonary endothelial fibrosis in response to hypoxia. |
| Protein Name | Homeobox Protein Nkx-2.5Cardiac-Specific HomeoboxHomeobox Protein CsxHomeobox Protein Nk-2 Homolog E |
| Database Links | Reactome: R-HSA-2032785Reactome: R-HSA-5578768Reactome: R-HSA-9733709 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Homeobox Protein Nkx-2.5 proteinCardiac-Specific Homeobox proteinHomeobox Protein Csx proteinHomeobox Protein Nk-2 Homolog E proteinNKX2-5 proteinCSX proteinNKX2.5 proteinNKX2E protein |
Information sourced from Uniprot.org