Human FIS1 protein (Recombinant) (His-Tag) (STJP016702)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human FIS1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FIS1 |
| Gene ID | 51024 |
| Uniprot ID | FIS1_HUMAN |
| Accession Number | NP_057152 |
| Immunogen | Human |
| Immunogen Region | 1-122aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Ubiquitinated by MARCHF5. |
| Function | Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event. Also mediates peroxisomal fission. May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. |
| Protein Name | Mitochondrial Fission 1 ProteinFis1 HomologHfis1Tetratricopeptide Repeat Protein 11Tpr Repeat Protein 11 |
| Database Links | Reactome: R-HSA-9603798 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Membrane ProteinPeroxisome Membrane |
| Alternative Protein Names | Mitochondrial Fission 1 Protein proteinFis1 Homolog proteinHfis1 proteinTetratricopeptide Repeat Protein 11 proteinTpr Repeat Protein 11 proteinFIS1 proteinTTC11 proteinCGI-135 protein |
Information sourced from Uniprot.org