SDS-PAGE gel of recombinant human ERLIN2 protein under reducing conditions stained with Coomassie blue

Human ERLIN2 protein (Recombinant) (His-Tag) (STJP017890)

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STJP017890
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Short Description :Recombinant-Human ERLIN2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE/Denatured
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2M urea, 20% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:ERLIN2
Gene ID:11160
Uniprot ID:ERLN2_HUMAN
Accession Number:NP_009106
Immunogen:Human
Immunogen Region:25-339aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MGSKIEEGHI GVYYRGGALL TSTSGPGFHL MLPFITSYKS VQTTLQTDEV KNVPCGTSGG VMIYFDRIEV VNFLVPNAVY DIVKNYTADY DKALIFNKIH HELNQFCSVH TLQEVYIELF DQIDENLKLA LQQDLTSMAP GLVIQAVRVT KPNIPEAIRR NYELMESEKT KLLIAAQKQK VVEKEAETER KKALIEAEKV AQVAEITY
Tissue Specificity Ubiquitous.
Post Translational Modifications Deubiquitinated by USP25.leading to stabilization.
Function Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex.
Protein Name Erlin-2
Endoplasmic Reticulum Lipid Raft-Associated Protein 2
Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 2
Spfh Domain-Containing Protein 2
Database Links Reactome: R-HSA-382556
Reactome: R-HSA-5655302
Reactome: R-HSA-5678895
Reactome: R-HSA-8853336
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type Ii Membrane Protein
Associated With Lipid Raft-Like Domains Of The Endoplasmic Reticulum Membrane
Alternative Protein Names Erlin-2 protein
Endoplasmic Reticulum Lipid Raft-Associated Protein 2 protein
Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 2 protein
Spfh Domain-Containing Protein 2 protein
ERLIN2 protein
C8orf2 protein
SPFH2 protein
UNQ2441 protein
PRO5003 protein
PRO9924 protein

Information sourced from Uniprot.org

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