Human ERLIN2 protein (Recombinant) (His-Tag) (STJP017890)

Name: Human ERLIN2 protein (Recombinant) (His-Tag) (STJP017890)
SKU: STJP017890
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SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP017890

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Short Description	Recombinant-Human ERLIN2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE/Denatured
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	1 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2M urea, 20% Glycerol
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	ERLIN2
Gene ID	11160
Uniprot ID	ERLN2_HUMAN
Accession Number	NP_009106
Immunogen	Human
Immunogen Region	25-339aa
Immunogen Sequence	MGSSHHHHHH SSGLVPRGSH MGSKIEEGHI GVYYRGGALL TSTSGPGFHL MLPFITSYKS VQTTLQTDEV KNVPCGTSGG VMIYFDRIEV VNFLVPNAVY DIVKNYTADY DKALIFNKIH HELNQFCSVH TLQEVYIELF DQIDENLKLA LQQDLTSMAP GLVIQAVRVT KPNIPEAIRR NYELMESEKT KLLIAAQKQK VVEKEAETER KKALIEAEKV AQVAEITY

Tissue Specificity	Ubiquitous.
Post Translational Modifications	Deubiquitinated by USP25.leading to stabilization.
Function	Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex.
Protein Name	Erlin-2 Endoplasmic Reticulum Lipid Raft-Associated Protein 2 Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 2 Spfh Domain-Containing Protein 2
Database Links	Reactome: R-HSA-382556 Reactome: R-HSA-5655302 Reactome: R-HSA-5678895 Reactome: R-HSA-8853336
Cellular Localisation	Endoplasmic Reticulum Membrane Single-Pass Type Ii Membrane Protein Associated With Lipid Raft-Like Domains Of The Endoplasmic Reticulum Membrane
Alternative Protein Names	Erlin-2 protein Endoplasmic Reticulum Lipid Raft-Associated Protein 2 protein Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 2 protein Spfh Domain-Containing Protein 2 protein ERLIN2 protein C8orf2 protein SPFH2 protein UNQ2441 protein PRO5003 protein PRO9924 protein

Information sourced from Uniprot.org