Human Cystatin-M/CST6 protein (Recombinant) (C-His) (STJP002603)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human Cystatin-M/CST6 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Arg29-Met149) of human CST6 (Accession #NP_001314.1) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human Cystatin-M/CST6-C-His protein was developed in hek293 cells using the region Arg29-Met149. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its ability to inhibit papain cleavage of a fluorogenic peptide substrate Z-FR-AMC. The IC50 value is approximately 16 nM. |
| Determination Method | < 0.01 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | CST6 |
| Gene ID | 1474 |
| Uniprot ID | CYTM_HUMAN |
| Immunogen | Recombinant Human Cystatin-M/CST6 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Arg29-Met149) of human CST6 (Accession #NP_001314.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Arg29-Met149 |
| Immunogen Sequence | RPQERMVGELRDLSPDDPQV QKAAQAAVASYNMGSNSIYY FRDTHIIKAQSQLVAGIKYF LTMEMGSTDCRKTRVTGDHV DLTTCPLAAGAQQEKLRCDF EVLVVPWQNSSQLLKHNCVQ M |
Additional Info
| Post Translational Modifications | Substrate for transglutaminases. Acts as an acyl acceptor but not as an acyl donor. |
| Function | High affinity inhibitor for cathepsin L, cathepsin L2 (cathepsin V), and legumain. Involved in the regulation of epidermal cornification, and hair follicle morphogenesis and maintenance. |
| Protein Name | Cystatin-MCystatin-6Cystatin-E |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Cystatin-M proteinCystatin-6 proteinCystatin-E proteinCST6 protein |
Information sourced from Uniprot.org