Human Cofilin 2/CFL2 protein (Recombinant) (His-Tag) (STJP017311)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Cofilin 2/CFL2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 10% Glycerol, 50mM Nacl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CFL2 |
| Gene ID | 1073 |
| Uniprot ID | COF2_HUMAN |
| Accession Number | NP_068733 |
| Immunogen | Human |
| Immunogen Region | 1-166aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MASGVTVNDE VIKVFNDMKV RKSSTQEEIK KRKKAVLFCL SDDKRQIIVE EAKQILVGDI GDTVEDPYTS FVKLLPLNDC RYALYDATYE TKESKKEDLV FIFWAPESAP LKSKMIYASS KDAIKKKFTG IKHEWQVNGL DDIKDRSTLG EKLGGNVVVS LEGKPL |
Additional Info
| Tissue Specificity | Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues. |
| Post Translational Modifications | The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal. |
| Function | Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere. |
| Protein Name | Cofilin-2Cofilin - Muscle Isoform |
| Database Links | |
| Cellular Localisation | Nucleus MatrixCytoplasmCytoskeletonColocalizes With Cspr3 In The Z Line Of Sarcomeres |
| Alternative Protein Names | Cofilin-2 proteinCofilin - Muscle Isoform proteinCFL2 protein |
Information sourced from Uniprot.org