Human Cofilin 2/CFL2 protein (Recombinant) (His-Tag) (STJP017311)

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STJP017311
€161.40 - €886.20
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Cofilin 2/CFL2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 10% Glycerol, 50mM Nacl
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: CFL2
Gene ID: 1073
Uniprot ID: COF2_HUMAN
Immunogen Region: 1-166aa
Accession Number: NP_068733
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MASGVTVNDE VIKVFNDMKV RKSSTQEEIK KRKKAVLFCL SDDKRQIIVE EAKQILVGDI GDTVEDPYTS FVKLLPLNDC RYALYDATYE TKESKKEDLV FIFWAPESAP LKSKMIYASS KDAIKKKFTG IKHEWQVNGL DDIKDRSTLG EKLGGNVVVS LEGKPL
Tissue Specificity Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues.
Post Translational Modifications The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.
Function Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere.
Protein Name Cofilin-2
Cofilin - Muscle Isoform
Database Links
Cellular Localisation Nucleus Matrix
Cytoplasm
Cytoskeleton
Colocalizes With Cspr3 In The Z Line Of Sarcomeres
Alternative Protein Names Cofilin-2 protein
Cofilin - Muscle Isoform protein
CFL2 protein

Information sourced from Uniprot.org

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