Name: Human CD161/KLRB1 protein (Recombinant) (His-Tag) (STJP017787)
SKU: STJP017787
Availability: InStock

Human CD161/KLRB1 protein (Recombinant) (His-Tag) (STJP017787)

SKU:

STJP017787

£134.50 - £738.50

Short Description :	Recombinant-Human CD161/KLRB1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:	SDS-PAGE/Denatured
Host:	E.coli
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration:	1 mg/mL
Formulation:	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% Glycerol
Storage Instruction:	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol:	KLRB1
Gene ID:	3820
Uniprot ID:	KLRB1_HUMAN
Accession Number:	NP_002249
Immunogen:	Human
Immunogen Region:	67-225aa
Immunogen Sequence:	QKSSIE KCSVDIQQSR NKTTERPGLL NCPIYWQQLR EKCLLFSHTV NPWNNSLADC STKESSLLLI RDKDELIHTQ NLIRDKAILF WIGLNFSLSE KNWKWINGSF LNSNDLEIRG DAKENSCISI SQTSVYSEYC STEIRWICQK ELTPVRNKVY PDS

Tissue Specificity	Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.
Post Translational Modifications	N-glycosylated. Contains sialic acid residues.
Function	Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Also binds to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Protein Name	Killer Cell Lectin-Like Receptor Subfamily B Member 1 C-Type Lectin Domain Family 5 Member B Hnkr-P1a Nkr-P1a Natural Killer Cell Surface Protein P1a Cd Antigen Cd161
Database Links	Reactome: R-HSA-198933
Cellular Localisation	Membrane Single-Pass Type Ii Membrane Protein
Alternative Protein Names	Killer Cell Lectin-Like Receptor Subfamily B Member 1 protein C-Type Lectin Domain Family 5 Member B protein Hnkr-P1a protein Nkr-P1a protein Natural Killer Cell Surface Protein P1a protein Cd Antigen Cd161 protein KLRB1 protein CLEC5B protein NKRP1A protein

Information sourced from Uniprot.org

Model	Name	Host	Application
STJP007090	Human CD161/KLRB1 protein (Recombinant) (C-His) (STJP007090)	Mammalian Cells	ELISA/Immunogen/SDS-PAGE/WB
STJP019895	Human KLRB1/CD161 protein (Recombinant) (C-His) (STJP019895)	HEK293 cells
STJP005271	Human CD161/KLRB1 protein (Recombinant) (N-His) (STJP005271)	E.coli	ELISA/Immunogen/SDS-PAGE/WB
STJP012658	Human CD161/KLRB1 protein (Recombinant-Active) (C-His) (STJP012658)	Mammalian Cells	ELISA/WB
STJP019894	Human KLRB1/CD161 protein (Recombinant) (C-His&Avi) {Biotin} (STJP019894)	HEK293 cells

Human CD161/KLRB1 protein (Recombinant) (His-Tag) (STJP017787)

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