Human CD161/KLRB1 protein (Recombinant) (His-Tag) (STJP017787)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CD161/KLRB1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KLRB1 |
| Gene ID | 3820 |
| Uniprot ID | KLRB1_HUMAN |
| Accession Number | NP_002249 |
| Immunogen | Human |
| Immunogen Region | 67-225aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype. |
| Post Translational Modifications | N-glycosylated. Contains sialic acid residues. |
| Function | Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Also binds to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. |
| Protein Name | Killer Cell Lectin-Like Receptor Subfamily B Member 1C-Type Lectin Domain Family 5 Member BHnkr-P1aNkr-P1aNatural Killer Cell Surface Protein P1aCd Antigen Cd161 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Killer Cell Lectin-Like Receptor Subfamily B Member 1 proteinC-Type Lectin Domain Family 5 Member B proteinHnkr-P1a proteinNkr-P1a proteinNatural Killer Cell Surface Protein P1a proteinCd Antigen Cd161 proteinKLRB1 proteinCLEC5B proteinNKRP1A protein |
Information sourced from Uniprot.org