Human C1qR/CD93 protein (Recombinant) (C-hFc&His) (STJP000939)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human C1qR/CD93 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala24-Lys580) of human CD93/C1QR1 (Accession #NP_036204.2) fused with an Fc, 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human C1qR/CD93-C-hFc&His protein was developed in hek293 cells using the region Ala24-Lys580. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | CD93 |
| Gene ID | 22918 |
| Uniprot ID | C1QR1_HUMAN |
| Immunogen | Recombinant Human C1qR/CD93 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala24-Lys580) of human CD93/C1QR1 (Accession #NP_036204.2) fused with an Fc, 6×His tag at the C-terminus. |
| Immunogen Region | Ala24-Lys580 |
| Immunogen Sequence | ADTEAVVCVGTACYTAHSGK LSAAEAQNHCNQNGGNLATV KSKEEAQHVQRVLAQLLRRE AALTARMSKFWIGLQREKGK CLDPSLPLKGFSWVGGGEDT PYSNWHKELRNSCISKRCVS LLLDLSQPLLPSRLPKWSEG PCGSPGSPGSNIEGFVCKFS FKGMCRPLALGGPGQVTYTT PFQTTSSSLEAVPFASAANV ACGEGDKDETQSHYFLCKEK APDVFDWGSSGPLCVSPKY |
Additional Info
| Tissue Specificity | Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin. |
| Post Translational Modifications | N- and O-glycosylated. Phosphorylated on Tyr-628 and Tyr-644 by SRC.these phosphorylations promote endothelial cell adhesion and migration. |
| Function | Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis. Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration. Participates in angiogenesis also by acting as a receptor for the ECM pan-endothelial glycoprotein multimerin-2/MMRN2 and IGFBP7 ligands. Both ligands play a non-redundant role in CD93-mediated endothelial cell function. Acts as a key regulator of endothelial barrier function through modulating VEGFR2 function. |
| Protein Name | Complement Component C1q ReceptorC1q/Mbl/Spa ReceptorC1qrC1qr(PC1qrpCdw93Complement Component 1 Q Subcomponent Receptor 1Matrix-Remodeling-Associated Protein 4Cd Antigen Cd93 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Complement Component C1q Receptor proteinC1q/Mbl/Spa Receptor proteinC1qr proteinC1qr(P proteinC1qrp proteinCdw93 proteinComplement Component 1 Q Subcomponent Receptor 1 proteinMatrix-Remodeling-Associated Protein 4 proteinCd Antigen Cd93 proteinCD93 proteinC1QR1 proteinMXRA4 protein |
Information sourced from Uniprot.org