• Human C1qR/CD93 protein (Recombinant) (C-hFc&His) (STJP000939)

Human C1qR/CD93 protein (Recombinant) (C-hFc&His) (STJP000939)

SKU:
STJP000939

£123.50 - £173.50
Current Stock:
Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Gene Symbol: CD93
Gene ID: 22918
Uniprot ID: C1QR1_HUMAN
Immunogen: Recombinant Human C1qR/CD93 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala24-Lys580) of human CD93/C1QR1 (Accession #NP_036204.2) fused with an Fc, 6×His tag at the C-terminus.
Immunogen Sequence: ADTEAVVCVGTACYTAHSGK LSAAEAQNHCNQNGGNLATV KSKEEAQHVQRVLAQLLRRE AALTARMSKFWIGLQREKGK CLDPSLPLKGFSWVGGGEDT PYSNWHKELRNSCISKRCVS LLLDLSQPLLPSRLPKWSEG PCGSPGSPGSNIEGFVCKFS FKGMCRPLALGGPGQVTYTT PFQTTSSSLEAVPFASAANV ACGEGDKDETQSHYFLCKEK APDVFDWGSSGPLCVSPKY
Tissue Specificity Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin.
Post Translational Modifications N- and O-glycosylated. Phosphorylated on Tyr-628 and Tyr-644 by SRC.these phosphorylations promote endothelial cell adhesion and migration.
Function Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis. Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration. Participates in angiogenesis also by acting as a receptor for the ECM pan-endothelial glycoprotein multimerin-2/MMRN2 and IGFBP7 ligands. Both ligands play a non-redundant role in CD93-mediated endothelial cell function. Acts as a key regulator of endothelial barrier function through modulating VEGFR2 function.
Protein Name Complement Component C1q Receptor
C1q/Mbl/Spa Receptor
C1qr
C1qr(P
C1qrp
Cdw93
Complement Component 1 Q Subcomponent Receptor 1
Matrix-Remodeling-Associated Protein 4
Cd Antigen Cd93
Database Links Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Complement Component C1q Receptor protein
C1q/Mbl/Spa Receptor protein
C1qr protein
C1qr(P protein
C1qrp protein
Cdw93 protein
Complement Component 1 Q Subcomponent Receptor 1 protein
Matrix-Remodeling-Associated Protein 4 protein
Cd Antigen Cd93 protein
CD93 protein
C1QR1 protein
MXRA4 protein

Information sourced from Uniprot.org

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