Human BPHL protein (Recombinant) (His-Tag) (STJP017008)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human BPHL-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 1mM DTT, 50mM NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BPHL |
| Gene ID | 670 |
| Uniprot ID | BPHL_HUMAN |
| Accession Number | NP_004323 |
| Immunogen | Human |
| Immunogen Region | 38-291aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MSVTSAKVAV NGVQLHYQQT GEGDHAVLLL PGMLGSGETD FGPQLKNLNK KLFTVVAWDP RGYGHSRPPD RDFPADFFER DAKDAVDLMK ALKFKKVSLL GWSDGGITAL IAAAKYPSYI HKMVIWGANA YVTDEDSMIY EGIRDVSKWS ERTRKPLEAL YGYDYFARTC EKWVDGIRQF KHLPDGNICR HLLPRVQCPA LIVHGEKD |
Additional Info
| Tissue Specificity | Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle. |
| Function | Specific alpha-amino acid ester serine hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. Has homocysteine-thiolactonase activity (in vitro) and may play a significant role in the detoxification of homocysteine thiolactone in vivo. Catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir, converting them into their active forms (acyclovir and ganciclovir). |
| Protein Name | Serine Hydrolase BphlBiphenyl Hydrolase-Like ProteinBiphenyl Hydrolase-Related ProteinBph-RpBreast Epithelial Mucin-Associated AntigenMcnaaL-Homocysteine-Thiolactonase BphlValacyclovir HydrolaseVacvaseValacyclovirase |
| Database Links | Reactome: R-HSA-211945 |
| Cellular Localisation | Mitochondrion |
| Alternative Protein Names | Serine Hydrolase Bphl proteinBiphenyl Hydrolase-Like Protein proteinBiphenyl Hydrolase-Related Protein proteinBph-Rp proteinBreast Epithelial Mucin-Associated Antigen proteinMcnaa proteinL-Homocysteine-Thiolactonase Bphl proteinValacyclovir Hydrolase proteinVacvase proteinValacyclovirase proteinBPHL proteinMCNAA protein |
Information sourced from Uniprot.org