GFRA-4 protein (STJP000151)

SKU:
STJP000151
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Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : GFRA-4-protein was developed from. For use in research applications.
Formulation: PBS pH 7.4
Purification: Purified by Ni-affinity chromatography and gel-filtration from serum-free CHO growth media
Concentration: 1.3 mg/ml
Storage Instruction: Store at-70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles
Gene Symbol: GFRA4
Gene ID: 64096
Uniprot ID: GFRA4_HUMAN
Tissue Specificity Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.
Function Receptor for persephin (PSPN), a growth factor that exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons. Acts by binding to its coreceptor, GFRA4, leading to autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.
Protein Name Gdnf Family Receptor Alpha-4
Gdnf Receptor Alpha-4
Gdnfr-Alpha-4
Gfr-Alpha-4
Persephin Receptor
Database Links Reactome: R-HSA-419037
Reactome: R-HSA-5673001
Reactome: R-HSA-8853659
Cellular Localisation Isoform Gfralpha4a: Cell Membrane
Lipid-Anchor
Gpi-Anchor
Isoform Gfralpha4b: Cell Membrane
Isoform Gfralpha4c: Secreted
Alternative Protein Names Gdnf Family Receptor Alpha-4 protein
Gdnf Receptor Alpha-4 protein
Gdnfr-Alpha-4 protein
Gfr-Alpha-4 protein
Persephin Receptor protein
GFRA4 protein

Information sourced from Uniprot.org

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