GFRA-4 protein (STJP000151)
SPECIFICATIONS
General Information
| Short Description | GFRA-4-protein was developed from. For use in research applications. |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1.3 mg/ml |
| Purification | Purified by Ni-affinity chromatography and gel-filtration from serum-free CHO growth media |
| Formulation | PBS pH 7.4 |
| Storage Instruction | Store at-70ยฐC upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles |
Target Information
| Gene Symbol | GFRA4 |
| Gene ID | 64096 |
| Uniprot ID | GFRA4_HUMAN |
Additional Info
| Tissue Specificity | Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands. |
| Function | Receptor for persephin (PSPN), a growth factor that exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons. Acts by binding to its coreceptor, GFRA4, leading to autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla. |
| Protein Name | Gdnf Family Receptor Alpha-4Gdnf Receptor Alpha-4Gdnfr-Alpha-4Gfr-Alpha-4Persephin Receptor |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Isoform Gfralpha4a: Cell MembraneLipid-AnchorGpi-AnchorIsoform Gfralpha4b: Cell MembraneIsoform Gfralpha4c: Secreted |
| Alternative Protein Names | Gdnf Family Receptor Alpha-4 proteinGdnf Receptor Alpha-4 proteinGdnfr-Alpha-4 proteinGfr-Alpha-4 proteinPersephin Receptor proteinGFRA4 protein |
Information sourced from Uniprot.org