| Host: |
Chicken |
| Applications: |
ELISA/WB/IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Chicken polyclonal antibody anti-GFRa-4 is suitable for use in ELISA, Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgY |
| Formulation: |
PBS pH 7.4 |
| Purification: |
GFRa-4 affinity purified |
| Dilution Range: |
WB 0.1 to 0.2 µg/ml; ELISA 3 to 6.7 ng/ml; IF 0.3 to 1 µg/ml Polyclonal antibody working titer has to be established practically for each particular antigen and assay format |
| Storage Instruction: |
Store at-20 to-70°C upon receipt. Divide antibody into aliquots prior usage. Avoid multiple freeze-thaw cycles. |
| Gene Symbol: |
GFRA4 |
| Gene ID: |
64096 |
| Uniprot ID: |
GFRA4_HUMAN |
| Specificity: |
Human GFRa-4, doesn t cross-react with hGFRa-1, hGFRa-2, hGFRa-3 |
| Immunogen: |
Recombinant His-tagged human GFRa-4 protein produced using CHO-based proprietary suspension cell line. For production of hGFRa-4, glycosylphosphatidyl-inositol GPI-anchor was removed and protein was secreted to the cell culture supernatant. Protein w |
| Tissue Specificity | Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands. |
| Function | Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla. |
| Protein Name | Gdnf Family Receptor Alpha-4Gdnf Receptor Alpha-4Gdnfr-Alpha-4Gfr-Alpha-4Persephin Receptor |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Isoform Gfralpha4a: Cell MembraneLipid-AnchorGpi-AnchorIsoform Gfralpha4b: Cell MembraneIsoform Gfralpha4c: Secreted |
| Alternative Antibody Names | Anti-Gdnf Family Receptor Alpha-4 antibodyAnti-Gdnf Receptor Alpha-4 antibodyAnti-Gdnfr-Alpha-4 antibodyAnti-Gfr-Alpha-4 antibodyAnti-Persephin Receptor antibodyAnti-GFRA4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
