Anti-GFRa-2 antibody (STJA0002878)
SPECIFICATIONS
ClonalityPolyclonal
HostChicken
ConjugationUnconjugated
IsotypeIgY
ImmunogenRecombinant His-tagged human GFR Alpha-2 protein produced using CHO-based proprietary suspension cell line. For production of hGFR Alpha-2, glycosylphosphatidyl-inositol GPI-anchor was removed and protein was secreted to the cell culture supernatant.
General Information
| Short Description | Chicken polyclonal anti-GFRa-2 for use in ELISA, WB and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/IF |
| Host | Chicken |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgY |
| Conjugation | Unconjugated |
| Purification | GFRa-2 affinity purified |
| Dilution Range | WB 0.2 to 1 µg/ml; ELISA 6.25 to 8 ng/ml; IF 1 to 2 µg/mlPolyclonal antibody working titer has to be established practically for each particular antigen and assay format |
| Formulation | Concentrated ammonium sulphate in PBS pH 7.4 |
| Storage Instruction | Store at +4°C upon receipt. As product is (NH4) 2SO4 precipitate, mix well by pipetting or vortexing prior use |
Target Information
| Gene Symbol | GFRA2 |
| Gene ID | 2675 |
| Uniprot ID | GFRA2_HUMAN |
| Immunogen | Recombinant His-tagged human GFR Alpha-2 protein produced using CHO-based proprietary suspension cell line. For production of hGFR Alpha-2, glycosylphosphatidyl-inositol GPI-anchor was removed and protein was secreted to the cell culture supernatant. |
| Specificity | Human GFRa-2, doesn t cross-react with hGFRa-1, hGFRa-3, hGFRa-4 |
Additional Info
| Tissue Specificity | Isoform 1: found in both brain and placenta. |
| Function | Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons. NRTN-binding leads to autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Isoform 2: Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3. |
| Protein Name | Gdnf Family Receptor Alpha-2Gdnf Receptor Alpha-2Gdnfr-Alpha-2Gfr-Alpha-2Gdnf Receptor BetaGdnfr-BetaNeurturin Receptor AlphaNrtnr-AlphaNtnr-AlphaRet Ligand 2Tgf-Beta-Related Neurotrophic Factor Receptor 2 |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Antibody Names | Anti-Gdnf Family Receptor Alpha-2 antibodyAnti-Gdnf Receptor Alpha-2 antibodyAnti-Gdnfr-Alpha-2 antibodyAnti-Gfr-Alpha-2 antibodyAnti-Gdnf Receptor Beta antibodyAnti-Gdnfr-Beta antibodyAnti-Neurturin Receptor Alpha antibodyAnti-Nrtnr-Alpha antibodyAnti-Ntnr-Alpha antibodyAnti-Ret Ligand 2 antibodyAnti-Tgf-Beta-Related Neurotrophic Factor Receptor 2 antibodyAnti-GFRA2 antibodyAnti-GDNFRB antibodyAnti-RETL2 antibodyAnti-TRNR2 antibody |
Information sourced from Uniprot.org