| Host: |
Chicken |
| Applications: |
ELISA/WB/IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Chicken polyclonal antibody anti-GFRa-2 is suitable for use in ELISA, Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgY |
| Formulation: |
Concentrated ammonium sulphate in PBS pH 7.4 |
| Purification: |
GFRa-2 affinity purified |
| Dilution Range: |
WB 0.2 to 1 µg/ml; ELISA 6.25 to 8 ng/ml; IF 1 to 2 µg/mlPolyclonal antibody working titer has to be established practically for each particular antigen and assay format |
| Storage Instruction: |
Store at +4°C upon receipt. As product is (NH4) 2SO4 precipitate, mix well by pipetting or vortexing prior use |
| Gene Symbol: |
GFRA2 |
| Gene ID: |
2675 |
| Uniprot ID: |
GFRA2_HUMAN |
| Specificity: |
Human GFRa-2, doesn t cross-react with hGFRa-1, hGFRa-3, hGFRa-4 |
| Immunogen: |
Recombinant His-tagged human GFR Alpha-2 protein produced using CHO-based proprietary suspension cell line. For production of hGFR Alpha-2, glycosylphosphatidyl-inositol GPI-anchor was removed and protein was secreted to the cell culture supernatant. |
| Tissue Specificity | Isoform 1 is found in both brain and placenta. |
| Function | Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Isoform 2: Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3. |
| Protein Name | Gdnf Family Receptor Alpha-2Gdnf Receptor Alpha-2Gdnfr-Alpha-2Gfr-Alpha-2Gdnf Receptor BetaGdnfr-BetaNeurturin Receptor AlphaNrtnr-AlphaNtnr-AlphaRet Ligand 2Tgf-Beta-Related Neurotrophic Factor Receptor 2 |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Antibody Names | Anti-Gdnf Family Receptor Alpha-2 antibodyAnti-Gdnf Receptor Alpha-2 antibodyAnti-Gdnfr-Alpha-2 antibodyAnti-Gfr-Alpha-2 antibodyAnti-Gdnf Receptor Beta antibodyAnti-Gdnfr-Beta antibodyAnti-Neurturin Receptor Alpha antibodyAnti-Nrtnr-Alpha antibodyAnti-Ntnr-Alpha antibodyAnti-Ret Ligand 2 antibodyAnti-Tgf-Beta-Related Neurotrophic Factor Receptor 2 antibodyAnti-GFRA2 antibodyAnti-GDNFRB antibodyAnti-RETL2 antibodyAnti-TRNR2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
