GFRA-2 protein (STJP000153)

SKU:
STJP000153
£352.50 - £1,119.50
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Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : GFRA-2-protein was developed from. For use in research applications.
Formulation: PBS pH 7.4
Purification: Purified by Ni-affinity chromatography and gel-filtration from serum-free CHO growth media
Concentration: 1.3 mg/ml
Storage Instruction: Store at-70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles
Gene Symbol: GFRA3
Gene ID: 2676
Uniprot ID: GFRA3_HUMAN
Tissue Specificity Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system.
Post Translational Modifications N-glycosylated.
Function Receptor for artemin (ARTN), a growth factor that supports the survival of sensory and sympathetic peripheral neurons. ARTN-binding leads to autophosphorylation and activation of the RET receptor.
Protein Name Gdnf Family Receptor Alpha-3
Gdnf Receptor Alpha-3
Gdnfr-Alpha-3
Gfr-Alpha-3
Database Links Reactome: R-HSA-5673001
Reactome: R-HSA-8853659
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Alternative Protein Names Gdnf Family Receptor Alpha-3 protein
Gdnf Receptor Alpha-3 protein
Gdnfr-Alpha-3 protein
Gfr-Alpha-3 protein
GFRA3 protein
UNQ339 protein
PRO538 protein
PRO3664 protein

Information sourced from Uniprot.org

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