| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
GFRA-2-protein was developed from. For use in research applications. |
| Formulation: |
PBS pH 7.4 |
| Purification: |
Purified by Ni-affinity chromatography and gel-filtration from serum-free CHO growth media |
| Concentration: |
1.3 mg/ml |
| Storage Instruction: |
Store at-70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles |
| Tissue Specificity | Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system. |
| Post Translational Modifications | N-glycosylated. |
| Function | Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase. |
| Protein Name | Gdnf Family Receptor Alpha-3Gdnf Receptor Alpha-3Gdnfr-Alpha-3Gfr-Alpha-3 |
| Database Links | Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Protein Names | Gdnf Family Receptor Alpha-3 proteinGdnf Receptor Alpha-3 proteinGdnfr-Alpha-3 proteinGfr-Alpha-3 proteinGFRA3 proteinUNQ339 proteinPRO538 proteinPRO3664 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
