Anti-GFRa-1 antibody (STJA0002877)
SPECIFICATIONS
ClonalityPolyclonal
HostChicken
ConjugationUnconjugated
IsotypeIgY
ImmunogenRecombinant His-tagged human GFRa-1 protein produced using CHO-based proprietary suspension cell line. For production of hGFRa-1, glycosylphosphatidyl-inositol GPI-anchor was removed and protein was secreted to the cell culture supernatant. Protein w
General Information
| Short Description | Chicken polyclonal anti-GFRa-1 for use in ELISA, WB and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/IF |
| Host | Chicken |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgY |
| Conjugation | Unconjugated |
| Purification | GFRa-1 affinity purified |
| Dilution Range | ELISA 0.02 to 0.05 µg/ml; WB 0.1 to 0.2 µg/ml; IF 0.5 to 1 µg/ml Polyclonal antibody working titer has to be established practically for each particular antigen and assay format |
| Formulation | Concentrated ammonium sulphate in PBS pH 7.4 |
| Storage Instruction | Store at +4 °C upon receipt. As product is (NH4) 2SO4 precipitate, mix well by pipetting or vortexing prior use |
Target Information
| Gene Symbol | GFRA1 |
| Gene ID | 2674 |
| Uniprot ID | GFRA1_HUMAN |
| Immunogen | Recombinant His-tagged human GFRa-1 protein produced using CHO-based proprietary suspension cell line. For production of hGFRa-1, glycosylphosphatidyl-inositol GPI-anchor was removed and protein was secreted to the cell culture supernatant. Protein w |
| Specificity | Human GFRa-1 doesn t cross-react with hGFRa-2, hGFRa-3, hGFRa-4 |
Additional Info
| Function | Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF-binding leads to autophosphorylation and activation of the RET receptor. |
| Protein Name | Gdnf Family Receptor Alpha-1Gdnf Receptor Alpha-1Gdnfr-Alpha-1Gfr-Alpha-1Ret Ligand 1Tgf-Beta-Related Neurotrophic Factor Receptor 1 |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659Reactome: R-HSA-9830674 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorGolgi ApparatusTrans-Golgi NetworkEndosomeMultivesicular BodyLocalizes Mainly To The Plasma MembraneIn The Presence Of Sorl1Shifts To Vesicular StructuresIncluding Trans-Golgi NetworkEndosomes And Multivesicular Bodies |
| Alternative Antibody Names | Anti-Gdnf Family Receptor Alpha-1 antibodyAnti-Gdnf Receptor Alpha-1 antibodyAnti-Gdnfr-Alpha-1 antibodyAnti-Gfr-Alpha-1 antibodyAnti-Ret Ligand 1 antibodyAnti-Tgf-Beta-Related Neurotrophic Factor Receptor 1 antibodyAnti-GFRA1 antibodyAnti-GDNFRA antibodyAnti-RETL1 antibodyAnti-TRNR1 antibody |
Information sourced from Uniprot.org