GFRA-2 protein (STJP000150)

SKU:
STJP000150
£352.50 - £1,119.50
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Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : GFRA-2-protein was developed from. For use in research applications.
Formulation: PBS pH 7.4
Concentration: 0.7 mg/ml
Storage Instruction: Store at-70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles
Gene Symbol: GFRA2
Gene ID: 2675
Uniprot ID: GFRA2_HUMAN
Tissue Specificity Isoform 1: found in both brain and placenta.
Function Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons. NRTN-binding leads to autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Isoform 2: Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.
Protein Name Gdnf Family Receptor Alpha-2
Gdnf Receptor Alpha-2
Gdnfr-Alpha-2
Gfr-Alpha-2
Gdnf Receptor Beta
Gdnfr-Beta
Neurturin Receptor Alpha
Nrtnr-Alpha
Ntnr-Alpha
Ret Ligand 2
Tgf-Beta-Related Neurotrophic Factor Receptor 2
Database Links Reactome: R-HSA-419037
Reactome: R-HSA-5673001
Reactome: R-HSA-8853659
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Alternative Protein Names Gdnf Family Receptor Alpha-2 protein
Gdnf Receptor Alpha-2 protein
Gdnfr-Alpha-2 protein
Gfr-Alpha-2 protein
Gdnf Receptor Beta protein
Gdnfr-Beta protein
Neurturin Receptor Alpha protein
Nrtnr-Alpha protein
Ntnr-Alpha protein
Ret Ligand 2 protein
Tgf-Beta-Related Neurotrophic Factor Receptor 2 protein
GFRA2 protein
GDNFRB protein
RETL2 protein
TRNR2 protein

Information sourced from Uniprot.org

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