| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
GFRA-2-protein was developed from. For use in research applications. |
| Formulation: |
PBS pH 7.4 |
| Concentration: |
0.7 mg/ml |
| Storage Instruction: |
Store at-70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles |
| Tissue Specificity | Isoform 1 is found in both brain and placenta. |
| Function | Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Isoform 2: Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3. |
| Protein Name | Gdnf Family Receptor Alpha-2Gdnf Receptor Alpha-2Gdnfr-Alpha-2Gfr-Alpha-2Gdnf Receptor BetaGdnfr-BetaNeurturin Receptor AlphaNrtnr-AlphaNtnr-AlphaRet Ligand 2Tgf-Beta-Related Neurotrophic Factor Receptor 2 |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Protein Names | Gdnf Family Receptor Alpha-2 proteinGdnf Receptor Alpha-2 proteinGdnfr-Alpha-2 proteinGfr-Alpha-2 proteinGdnf Receptor Beta proteinGdnfr-Beta proteinNeurturin Receptor Alpha proteinNrtnr-Alpha proteinNtnr-Alpha proteinRet Ligand 2 proteinTgf-Beta-Related Neurotrophic Factor Receptor 2 proteinGFRA2 proteinGDNFRB proteinRETL2 proteinTRNR2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
