| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
FPR1 Blocking Peptide for STJ501083 is synthetically produced from the 150-200 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
FPR1 |
| Gene ID: |
2357 |
| Uniprot ID: |
FPR1_HUMAN |
| Immunogen Region: |
150-200 |
| Specificity: |
This blocking peptide is recommended for use in combination with FPR1 antibody, STJ501083 |
| Immunogen: |
Synthetic peptide taken within amino acid region 150-200 on N-formyl peptide receptor. |
| Tissue Specificity | Neutrophils. |
| Post Translational Modifications | Phosphorylated.which is necessary for desensitization. |
| Function | High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release. Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis. |
| Peptide Name | Fmet-Leu-Phe ReceptorFmlp ReceptorN-Formyl Peptide ReceptorFprN-Formylpeptide Chemoattractant Receptor |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-444473Reactome: R-HSA-6783783Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInternalizes In Presence Of Its LigandsFmlpTafa4 And Ctsg |
| Alternative Peptide Names | Fmet-Leu-Phe Receptor proteinFmlp Receptor proteinN-Formyl Peptide Receptor proteinFpr proteinN-Formylpeptide Chemoattractant Receptor proteinFPR1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
