FPR1 Blocking Peptide for STJ501083 peptide (STJ505336)
SPECIFICATIONS
ImmunogenSynthetic peptide taken within amino acid region 150-200 on N-formyl peptide receptor.
General Information
| Short Description | FPR1 Blocking Peptide for STJ501083 is synthetically produced from the 150-200 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | FPR1 |
| Gene ID | 2357 |
| Uniprot ID | FPR1_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 150-200 on N-formyl peptide receptor. |
| Immunogen Region | 150-200 |
| Specificity | This blocking peptide is recommended for use in combination with FPR1 antibody, STJ501083 |
Additional Info
| Tissue Specificity | Neutrophils. |
| Post Translational Modifications | Phosphorylated.which is necessary for desensitization. |
| Function | High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release. Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis. |
| Peptide Name | Fmet-Leu-Phe ReceptorFmlp ReceptorN-Formyl Peptide ReceptorFprN-Formylpeptide Chemoattractant Receptor |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-444473Reactome: R-HSA-6783783Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInternalizes In Presence Of Its LigandsFmlpTafa4 And Ctsg |
| Alternative Peptide Names | Fmet-Leu-Phe Receptor proteinFmlp Receptor proteinN-Formyl Peptide Receptor proteinFpr proteinN-Formylpeptide Chemoattractant Receptor proteinFPR1 protein |
Information sourced from Uniprot.org