Host: | Goat |
Applications: | Pep-ELISA/WB |
Reactivity: | Human/Cow |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Goat polyclonal antibody anti-TSHR (101-115) is suitable for use in ELISA and Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Concentration: | 0.5 mg/mL |
Dilution Range: | WB-0.5-2µg/ml ELISA-antibody detection limit dilution 1:16000. |
Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Gene Symbol: | TSHR |
Gene ID: | 7253 |
Uniprot ID: | TSHR_HUMAN |
Immunogen Region: | 101-115 |
Accession Number: | NP_000360.2; NP_001018046.1 |
Specificity: | This antibody is expected to recognize reported isoform 1 (NP_000360.2) and isoform 2 (NP_001018046.1). The immunizing peptide sequence corresponds to a part of the extracellular domain. |
Immunogen Sequence: | SKVTHIEIRNTRNLT |
Post Translational Modifications | Glycosylated. Sulfated. Sulfation on Tyr-385 plays a role in thyrotropin receptor binding and activation. |
Function | Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. |
Protein Name | Thyrotropin Receptor Thyroid-Stimulating Hormone Receptor Tsh-R |
Database Links | Reactome: R-HSA-375281 Reactome: R-HSA-418555 |
Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Basolateral Cell Membrane |
Alternative Antibody Names | Anti-Thyrotropin Receptor antibody Anti-Thyroid-Stimulating Hormone Receptor antibody Anti-Tsh-R antibody Anti-TSHR antibody Anti-LGR3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance