• STJ72663 (0. 5µg/ml) staining of Human Thyroid gland lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-TSHR antibody (101-115) (STJ72663)

SKU:
STJ72663-100

£303.50
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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-TSHR (101-115) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.5-2µg/ml
ELISA-antibody detection limit dilution 1:16000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: TSHR
Gene ID: 7253
Uniprot ID: TSHR_HUMAN
Immunogen Region: 101-115
Accession Number: NP_000360.2; NP_001018046.1
Specificity: This antibody is expected to recognize reported isoform 1 (NP_000360.2) and isoform 2 (NP_001018046.1). The immunizing peptide sequence corresponds to a part of the extracellular domain.
Immunogen Sequence: SKVTHIEIRNTRNLT
Post Translational Modifications Glycosylated. Sulfated. Sulfation on Tyr-385 plays a role in thyrotropin receptor binding and activation.
Function Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
Protein Name Thyrotropin Receptor
Thyroid-Stimulating Hormone Receptor
Tsh-R
Database Links Reactome: R-HSA-375281
Reactome: R-HSA-418555
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Basolateral Cell Membrane
Alternative Antibody Names Anti-Thyrotropin Receptor antibody
Anti-Thyroid-Stimulating Hormone Receptor antibody
Anti-Tsh-R antibody
Anti-TSHR antibody
Anti-LGR3 antibody

Information sourced from Uniprot.org

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