Anti-TSHR antibody (101-115) (STJ72663)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-TSHR (101-115) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 28kDa band observed in Human Thyroid Gland lysates (calculated MW of 28.4kDa according to NP_001018046.1). Recommended concentration: 0.5-2µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | TSHR |
| Gene ID | 7253 |
| Uniprot ID | TSHR_HUMAN |
| Accession Number | NP_000360.2; NP_001018046.1 |
| Immunogen Region | 101-115 |
| Immunogen Sequence | SKVTHIEIRNTRNLT |
| Specificity | This antibody is expected to recognize reported isoform 1 (NP_000360.2) and isoform 2 (NP_001018046.1). The immunizing peptide sequence corresponds to a part of the extracellular domain. |
Additional Info
| Post Translational Modifications | Glycosylated. Sulfated. Sulfation on Tyr-385 plays a role in thyrotropin receptor binding and activation. |
| Function | Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. |
| Protein Name | Thyrotropin ReceptorThyroid-Stimulating Hormone ReceptorTsh-R |
| Database Links | Reactome: R-HSA-375281Reactome: R-HSA-418555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell Membrane |
| Alternative Antibody Names | Anti-Thyrotropin Receptor antibodyAnti-Thyroid-Stimulating Hormone Receptor antibodyAnti-Tsh-R antibodyAnti-TSHR antibodyAnti-LGR3 antibody |
Information sourced from Uniprot.org