| Tissue Specificity | Up-regulated in gastric adenocarcinomas. |
| Post Translational Modifications | Auto-ubiquitinated (in vitro). |
| Function | E3 ubiquitin-protein ligase that acts as a regulator of antiviral immune response and inflammation by mediating ubiquitination of substrates. Acts as a regulator of innate immune defense against viruses by mediating 'Lys-63'-linked ubiquitination of MAVS, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria. Acts as a negative regulator of the NLRP3 inflammasome by catalyzing 'Lys-48'-linked ubiquitination of NLRP3, leading to its degradation. Regulator of Src-induced anchorage independent cell growth. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim31Tripartite Motif-Containing Protein 31 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | CytoplasmMitochondrionPredominantly Expressed In The Cytoplasm But A Fraction Is Associated With The MitochondriaRecruited T Omitochondria After Viral Infection |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim31 antibodyAnti-Tripartite Motif-Containing Protein 31 antibodyAnti-TRIM31 antibodyAnti-C6orf13 antibodyAnti-RNF antibody |
Information sourced from Uniprot.org
