Host: |
Rabbit |
Applications: |
WB/IF |
Reactivity: |
Human/Mouse/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-TRIM23 (1-280) is suitable for use in Western Blot and Immunofluorescence research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: |
Affinity purification |
Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
TRIM23 |
Gene ID: |
373 |
Uniprot ID: |
TRI23_HUMAN |
Immunogen Region: |
1-280 |
Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human TRIM23 (NP_001647.1). |
Immunogen Sequence: |
MATLVVNKLGAGVDSGRQGS RGTAVVKVLECGVCEDVFSL QGDKVPRLLLCGHTVCHDCL TRLPLHGRAIRCPFDRQVTD LGDSGVWGLKKNFALLELLE RLQNGPIGQYGAAEESIGIS GESIIRCDEDEAHLASVYCT VCATHLCSECSQVTHSTKTL AKHRRVPLADKPHEKTMCSQ HQVHAIEFVCLEEGCQTSPL MCCVCKEYGKHQGHKHSVLE PEANQIRASILDMAHCIRT |
Function | Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes. (Microbial infection) Mediates TRAF6 auto-ubiquitination in the presence of human cytomegalovirus protein UL144, resulting in the virally controlled activation of NF-kappa-B stimulation at early times of HCMV infection. |
Protein Name | E3 Ubiquitin-Protein Ligase Trim23Adp-Ribosylation Factor Domain-Containing Protein 1Gtp-Binding Protein Ard-1Ring Finger Protein 46Ring-Type E3 Ubiquitin Transferase Trim23Tripartite Motif-Containing Protein 23 |
Cellular Localisation | CytoplasmEndomembrane SystemGolgi Apparatus MembraneLysosome MembraneMembrane-Associated With The Golgi Complex And Lysosomal Structures |
Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim23 antibodyAnti-Adp-Ribosylation Factor Domain-Containing Protein 1 antibodyAnti-Gtp-Binding Protein Ard-1 antibodyAnti-Ring Finger Protein 46 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Trim23 antibodyAnti-Tripartite Motif-Containing Protein 23 antibodyAnti-TRIM23 antibodyAnti-ARD1 antibodyAnti-ARFD1 antibodyAnti-RNF46 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance