| Function | Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response. |
| Protein Name | Protein O-Mannosyl-Transferase Tmtc3Protein SmileTransmembrane O-Mannosyltransferase Targeting Cadherins 3Transmembrane And Tetratricopeptide Repeat-Containing 3 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinEndoplasmic ReticulumIn Odontoblast CulturesIt Colocalizes With Pdia3 In The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Protein O-Mannosyl-Transferase Tmtc3 antibodyAnti-Protein Smile antibodyAnti-Transmembrane O-Mannosyltransferase Targeting Cadherins 3 antibodyAnti-Transmembrane And Tetratricopeptide Repeat-Containing 3 antibodyAnti-TMTC3 antibody |
Information sourced from Uniprot.org
