• Immunohistochemistry analysis of DSG3/Desmoglein-3 in paraffin-embedded human lung squamous carcinoma tissue tissue using DSG3/Desmoglein-3 Rabbit polyclonal antibody (STJ11105563) at a dilution of 1:100 (40x lens). High pressure antigen retrieval was performed with 0. 01 M citrate buffer (pH 6. 0) prior to immunohistochemistry staining.

Anti-DSG3 antibody (50-615) (STJ11105563)

SKU:
STJ11105563

Current Stock:
Host: Rabbit
Applications: IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Desmoglein-3 (50-615) is suitable for use in Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DSG3
Gene ID: 1830
Uniprot ID: DSG3_HUMAN
Immunogen Region: 50-615
Immunogen: Recombinant Protein corresponding to a sequence within amino acids 50-615 of human DSG3/Desmoglein-3 (NP_001935.2).
Immunogen Sequence: EWVKFAKPCREGEDNSKRNP IAKITSDYQATQKITYRISG VGIDQPPFGIFVVDKNTGDI NITAIVDREETPSFLITCRA LNAQGLDVEKPLILTVKILD INDNPPVFSQQIFMGEIEEN SASNSLVMILNATDADEPNH LNSKIAFKIVSQEPAGTPMF LLSRNTGEVRTLTNSLDREQ ASSYRLVVSGADKDGEGLST QCECNIKVKDVNDNFPMFRD SQYSARIEENILSSELLRF
Tissue Specificity Epidermis, tongue, tonsil, esophagus and carcinomas. Expressed in skin and mucosa (at protein level).
Function Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Protein Name Desmoglein-3
130 Kda Pemphigus Vulgaris Antigen
Pva
Cadherin Family Member 6
Database Links Reactome: R-HSA-351906
Reactome: R-HSA-6805567
Reactome: R-HSA-6809371
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Desmosome
Alternative Antibody Names Anti-Desmoglein-3 antibody
Anti-130 Kda Pemphigus Vulgaris Antigen antibody
Anti-Pva antibody
Anti-Cadherin Family Member 6 antibody
Anti-DSG3 antibody
Anti-CDHF6 antibody

Information sourced from Uniprot.org

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