Anti-TMTC3 antibody (615-914) (STJ116811)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TMTC3 (615-914) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TMTC3 |
| Gene ID | 160418 |
| Uniprot ID | TMTC3_HUMAN |
| Immunogen Region | 615-914 |
| Immunogen Sequence | EALKNFNRALELNPKHKLAL FNSAIVMQESGEVKLRPEAR KRLLSYINEEPLDANGYFNL GMLAMDDKKDNEAEIWMKKA IKLQADFRSALFNLALLYSQ TAKELKALPILEELLRYYPD HIKGLILKGDILMNQKKDIL GAKKCFERILEMDPSNVQGK HNLCVVYFEEKDLLKAERCL LETLALAPHEEYIQRHLNIV RDKISSSSFIEPIFPTSKIS SVEGKKIPTESVKEIRGES |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 615-914 of human TMTC3 (NP_861448.2). |
Additional Info
| Function | Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response. |
| Protein Name | Protein O-Mannosyl-Transferase Tmtc3Protein SmileTransmembrane O-Mannosyltransferase Targeting Cadherins 3Transmembrane And Tetratricopeptide Repeat-Containing 3 |
| Database Links | |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinEndoplasmic ReticulumIn Odontoblast CulturesIt Colocalizes With Pdia3 In The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Protein O-Mannosyl-Transferase Tmtc3 antibodyAnti-Protein Smile antibodyAnti-Transmembrane O-Mannosyltransferase Targeting Cadherins 3 antibodyAnti-Transmembrane And Tetratricopeptide Repeat-Containing 3 antibodyAnti-TMTC3 antibody |
Information sourced from Uniprot.org