• Western blot analysis of various lysates using TMTC3 Rabbit polyclonal antibody (STJ116811) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.

Anti-TMTC3 antibody (615-914) (STJ116811)

SKU:
STJ116811

$151.88 - $705.38
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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TMTC3 (615-914) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TMTC3
Gene ID: 160418
Uniprot ID: TMTC3_HUMAN
Immunogen Region: 615-914
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 615-914 of human TMTC3 (NP_861448.2).
Immunogen Sequence: EALKNFNRALELNPKHKLAL FNSAIVMQESGEVKLRPEAR KRLLSYINEEPLDANGYFNL GMLAMDDKKDNEAEIWMKKA IKLQADFRSALFNLALLYSQ TAKELKALPILEELLRYYPD HIKGLILKGDILMNQKKDIL GAKKCFERILEMDPSNVQGK HNLCVVYFEEKDLLKAERCL LETLALAPHEEYIQRHLNIV RDKISSSSFIEPIFPTSKIS SVEGKKIPTESVKEIRGES
Function Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response.
Protein Name Protein O-Mannosyl-Transferase Tmtc3
Protein Smile
Transmembrane And Tpr Repeat-Containing Protein 3
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum
In Odontoblast Cultures
It Colocalizes With Pdia3 In The Endoplasmic Reticulum
Alternative Antibody Names Anti-Protein O-Mannosyl-Transferase Tmtc3 antibody
Anti-Protein Smile antibody
Anti-Transmembrane And Tpr Repeat-Containing Protein 3 antibody
Anti-TMTC3 antibody

Information sourced from Uniprot.org

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