| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TMTC3 (615-914) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TMTC3 |
| Gene ID: |
160418 |
| Uniprot ID: |
TMTC3_HUMAN |
| Immunogen Region: |
615-914 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 615-914 of human TMTC3 (NP_861448.2). |
| Immunogen Sequence: |
EALKNFNRALELNPKHKLAL FNSAIVMQESGEVKLRPEAR KRLLSYINEEPLDANGYFNL GMLAMDDKKDNEAEIWMKKA IKLQADFRSALFNLALLYSQ TAKELKALPILEELLRYYPD HIKGLILKGDILMNQKKDIL GAKKCFERILEMDPSNVQGK HNLCVVYFEEKDLLKAERCL LETLALAPHEEYIQRHLNIV RDKISSSSFIEPIFPTSKIS SVEGKKIPTESVKEIRGES |
| Function | Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response. |
| Protein Name | Protein O-Mannosyl-Transferase Tmtc3Protein SmileTransmembrane And Tpr Repeat-Containing Protein 3 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinEndoplasmic ReticulumIn Odontoblast CulturesIt Colocalizes With Pdia3 In The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Protein O-Mannosyl-Transferase Tmtc3 antibodyAnti-Protein Smile antibodyAnti-Transmembrane And Tpr Repeat-Containing Protein 3 antibodyAnti-TMTC3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
