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Anti-TLE1 antibody (175-338aa) [ZM93] (STJ180329)

Human synovial sarcoma stained with anti-TLE1 antibody using peroxidase-conjugate and DAB chromogen. Note nuclear staining of tumor cells.

Anti-TLE1 antibody (175-338aa) [ZM93] (STJ180329)

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STJ180329

$228.83 - $901.13

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Host:	Mouse
Applications:	IHC-P
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-TLE1 (175-338aa) is suitable for use in Immunohistochemistry research applications.

Clonality:	Monoclonal
Clone ID:	ZM93
Conjugation:	Unconjugated
Isotype:	IgG2a/Kappa
Formulation:	Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Purification:	Affinity purified
Dilution Range:	1:100‐200
Storage Instruction:	Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.

Gene Symbol:	TLE1
Gene ID:	7088
Uniprot ID:	TLE1_HUMAN
Immunogen Region:	175-338aa
Specificity:	Positive control: Synovial sarcoma
Immunogen:	Recombinant human TLE1 fragment (aa 175-338)

Tissue Specificity	In all tissues examined, mostly in brain, liver and muscle.
Post Translational Modifications	Phosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1. Ubiquitinated by XIAP/BIRC4.
Function	Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Protein Name	Transducin-Like Enhancer Protein 1 E(Sp1 Homolog Enhancer Of Split Groucho-Like Protein 1 Esg1
Database Links	Reactome: R-HSA-201722 Reactome: R-HSA-2122947 Reactome: R-HSA-3769402 Reactome: R-HSA-4641265
Cellular Localisation	Nucleus Nuclear And Chromatin-Associated Depending On Isoforms And Phosphorylation Status Hyperphosphorylation Decreases The Affinity For Nuclear Components
Alternative Antibody Names	Anti-Transducin-Like Enhancer Protein 1 antibody Anti-E(Sp1 Homolog antibody Anti-Enhancer Of Split Groucho-Like Protein 1 antibody Anti-Esg1 antibody Anti-TLE1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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