| Host: |
Mouse |
| Applications: |
IHC-P |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-TLE1 (175-338aa) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
ZM93 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG2a/Kappa |
| Formulation: |
Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin |
| Purification: |
Affinity purified |
| Dilution Range: |
1:100‐200 |
| Storage Instruction: |
Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C. |
| Gene Symbol: |
TLE1 |
| Gene ID: |
7088 |
| Uniprot ID: |
TLE1_HUMAN |
| Immunogen Region: |
175-338aa |
| Specificity: |
Positive control: Synovial sarcoma |
| Immunogen: |
Recombinant human TLE1 fragment (aa 175-338) |
| Tissue Specificity | In all tissues examined, mostly in brain, liver and muscle. |
| Post Translational Modifications | Phosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1. Ubiquitinated by XIAP/BIRC4. |
| Function | Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. |
| Protein Name | Transducin-Like Enhancer Protein 1E(Sp1 HomologEnhancer Of Split Groucho-Like Protein 1Esg1 |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-2122947Reactome: R-HSA-3769402Reactome: R-HSA-4641265 |
| Cellular Localisation | NucleusNuclear And Chromatin-AssociatedDepending On Isoforms And Phosphorylation StatusHyperphosphorylation Decreases The Affinity For Nuclear Components |
| Alternative Antibody Names | Anti-Transducin-Like Enhancer Protein 1 antibodyAnti-E(Sp1 Homolog antibodyAnti-Enhancer Of Split Groucho-Like Protein 1 antibodyAnti-Esg1 antibodyAnti-TLE1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Anti-TLE1 antibody (150-250) [S9MR] (STJ11101889)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/90804/361125/STJ11101889_1__54688.1713125908.jpg?c=1 "Anti-TLE1 antibody (150-250) [S9MR] (STJ11101889)")
