| Tissue Specificity | Preferentially expressed in the placenta. |
| Function | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. |
| Protein Name | Transcriptional Enhancer Factor Tef-5Dtef-1Tea Domain Family Member 3Tead-3 |
| Database Links | Reactome: R-HSA-2032785Reactome: R-HSA-8951671 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcriptional Enhancer Factor Tef-5 antibodyAnti-Dtef-1 antibodyAnti-Tea Domain Family Member 3 antibodyAnti-Tead-3 antibodyAnti-TEAD3 antibodyAnti-TEAD5 antibodyAnti-TEF5 antibody |
Information sourced from Uniprot.org
