| Short Description : | Rabbit polyclonal TEAD3 (130-330) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TEAD3 |
| Gene ID: | 7005 |
| Uniprot ID: | TEAD3_HUMAN |
| Immunogen Region: | 130-330 |
| Immunogen Sequence: | SSAQIVSASVLQNKFSPPSP LPQAVFSTSSRFWSSPPLLG QQPGPSQDIKPFAQPAYPIQ PPLPPTLSSYEPLAPLPSAA ASVPVWQDRTIASSRLRLLE YSAFMEVQRDPDTYSKHLFV HIGQTNPAFSDPPLEAVDVR QIYDKFPEKKGGLKELYEKG PPNAFFLVKFWADLNSTIQE GPGAFYGVSSQYSSADSMTI S |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-330 of human TEAD3 (NP_003205.2). |
| Tissue Specificity | Preferentially expressed in the placenta. |
| Function | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. |
| Protein Name | Transcriptional Enhancer Factor Tef-5Dtef-1Tea Domain Family Member 3Tead-3 |
| Database Links | Reactome: R-HSA-2032785Reactome: R-HSA-8951671 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcriptional Enhancer Factor Tef-5 antibodyAnti-Dtef-1 antibodyAnti-Tea Domain Family Member 3 antibodyAnti-Tead-3 antibodyAnti-TEAD3 antibodyAnti-TEAD5 antibodyAnti-TEF5 antibody |
Information sourced from Uniprot.org
