Anti-TBCB antibody (1-244) (STJ115213)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TBCB (1-244) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TBCB |
| Gene ID | 1155 |
| Uniprot ID | TBCB_HUMAN |
| Immunogen Region | 1-244 |
| Immunogen Sequence | MEVTGVSAPTVTVFISSSLN TFRSEKRYSRSLTIAEFKCK LELLVGSPASCMELELYGVD DKFYSKLDQEDALLGSYPVD DGCRIHVIDHSGARLGEYED VSRVEKYTISQEAYDQRQDT VRSFLKRSKLGRYNEEERAQ QEAEAAQRLAEEKAQASSIP VGSRCEVRAAGQSPRRGTVM YVGLTDFKPGYWIGVRYDEP LGKNDGSVNGKRYFECQAKY GAFVKPAVVTVGDFPEEDY |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-244 of human TBCB (NP_001272.2). |
Additional Info
| Tissue Specificity | Found in most tissues. |
| Post Translational Modifications | Phosphorylation by PAK1 is required for normal function. Ubiquitinated in the presence of GAN which targets it for degradation by the proteasome. (Microbial infection) Glycosylated residues by S.typhimurium protein Ssek1: arginine GlcNAcylation promotes microtubule stability. |
| Function | Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth. |
| Protein Name | Tubulin-Folding Cofactor BCytoskeleton-Associated Protein 1Cytoskeleton-Associated Protein CkapiTubulin-Specific Chaperone B |
| Database Links | Reactome: R-HSA-389977 |
| Cellular Localisation | CytoplasmCytoskeletonColocalizes With MicrotubulesIn Differentiated NeuronsLocated In The CytoplasmIn Differentiating NeuronsAccumulates At The Growth Cone |
| Alternative Antibody Names | Anti-Tubulin-Folding Cofactor B antibodyAnti-Cytoskeleton-Associated Protein 1 antibodyAnti-Cytoskeleton-Associated Protein Ckapi antibodyAnti-Tubulin-Specific Chaperone B antibodyAnti-TBCB antibodyAnti-CG22 antibodyAnti-CKAP1 antibody |
Information sourced from Uniprot.org